This article is devoted to the legal regulation of the use of genomic editing technology in individual states. In general, it can be stated that in most legal systems there are restrictions on genomic editing in relation to hereditary genes, however, in rare cases exceptions are allowed, which must be recognized as justified in view of the reality of threats to human life and health. Using the method of comparative legal analysis, the author identifies the most optimal experience that can be useful to the domestic system of law-making on the way to forming legislation in the field of public health protection.